Platform

Innovative Technology

Arch intends to transform the landscape of interventional healthcare with products to seal and protect leaking and bleeding tissue. Arch's elegant platform technology controls the movement of fluids and substances. Starting materials - such as peptides - 'self-assemble' into a nanoscale fiber network on contact with a charged environment, immediately providing a barrier that keeps fluids in and contaminants out. Arch's platform technology Is effective, simple, versatile and safe. Arch's platform of self-assembling peptide (and peptidomimetic) barriers (SAPBs) can become an important tool in several applications.

Physicians, industry and patients could benefit from a universal sealant for the challenges presented when an opening is created in the body, whether via surgery, trauma, colonoscopy biopsy, device implantation, chronic wound management or in a variety of other settings. The clinician or surgeon must manage and preferably prevent bleeding and leakage, as well as other challenges. Currently available tools designed to resolve these problems are often inadequate.

• Immediate and effective barrier formation. The barrier that assembles on contact, within seconds, stops bleeding (hemostasis) promptly, without reliance on pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. Unlike many competitive products, SAPBs conform to irregular wound geometry, and provide a microenvironment for normal healing.
• Biocompatible and easy to work with. Because the SAPBs are not sticky or glue-like, and don't require a dry surface, they may be ideal for use in minimally invasive surgery - a challenge for much of the competition, or open surgery. Furthermore, the barrier is transparent, enabling a surgeon to operate through it in order to prophylactically stop bleeding as it starts - an important advancement we call Crystal Clear Surgery™. To date, in preclinical and clinical tests, biocompatibility has been excellent, and healing of tissue treated with the device has been normal
• Versatile. In animal studies, the material has been applied in a number of applications including brain, spinal cord, femoral artery, liver, or skin of mammals. In vitro and preclinical applications have ranged from hemostatic effect to tissue regeneration.
• Synthetic, scalable manufacturing. Most of our SAPBs contain naturally-occurring materials made from chemical processes, not animal sources. This provides for biocompatibility, good batch-to-batch reproducibility, no avenue for transmission of animal-borne infectious agents or contaminants, and a low risk of adverse events.

Arch Therapeutics' platform is covered by an intellectual property portfolio of licensed or assigned granted and pending patents in multiple geographic jurisdictions covering compositions and methods of use in a variety of applications.

AC5 Advanced Wound System and AC5 Topical Hemostat¹

Visual appearance of assembled nanofiber network

¹AC5 and associated logos are trademarks and/or registered trademarks of Arch Therapeutics, Inc. and/or its subsidiaries.